Biogelx’s new generation bioink hydrogel scaffolds are based on a two-peptide system: a hydrophobic ‘gelator’ peptide (Fmoc-diphenylalanine), and a hydrophilic ‘surfactant’ (Fmoc-serine). The peptides self-assemble to form fibres in aqueous environments. In the presence of Ca2+ ions, these nanofibers cross-link to form the hydrogel. The result is a nanofibrous network with a similar nanoscale matrix structure to that of the native extracellular matrix (ECM) in human tissue.
Biogelx™-INK has rheological properties that have been optimized for bioprinting applications and can be printed with great fidelity to provide a self-supporting 3D scaffold.