Organ on a chip tissuse
Technology
TissUse has developed a unique, proprietary and patent-protected “human-on-a-chip” technology platform to accelerate the development of pharmaceutical, chemical, cosmetic, and personalized medical products.
This technology – for the first time ever – provides preclinical insight on a systemic level using human tissue and enables the direct prediction of effects of chemicals and their metabolism on near real-life models.
The partnership between 3DBS and TissUse aims to offer “organ on a chip” technology to researchers working in the field of tissue engineering and regenerative medicine through a complete pipeline from the manufacture and offering of bioprinted in vitro models, to the systemic evaluation of their interaction using TissUse’s HUMIMIC technology.
TissUse Multi-Organ-Chip platform covers a broad field of applications:
TissUse’s proprietary technology platform is a miniaturised construct that closely simulates the activity of multiple human organs in their true physiological context at the smallest possible biological scale.
Microfluidic chip format of a standard microscopic slide
- Tissue cultures 100,000-fold smaller than original organs
- Dynamic circulation with vascular perfusion
- On-chip micro-pump and natural tissue to fluid ratio
- Variable physiological shear stresses applicable
- Compatible with life tissue imaging
- Designed to work with existing lab equipment
- Rapid prototyping of any relevant chip design
HUMIMIC CHIPS are tailored to your needs and your HUMIMIC Control Units. The choice of tissue source is yours: Regardless of whether you are using cell lines, primary cells, biopsies, tissue sections, or commercially available models, HUMIMIC chips provide a reliable platform for all your experiments. Interested in working with iPSCs? You can conveniently combine HUMIMIC iPSCs with HUMIMIC chips.
HUMIMIC Chip2
The HUMIMC Chip2 allows the simultaneous culture of two different organ models. Cells and tissues can be used to emulate biological barriers like the intestine, lung or skin, as well as to grow spheroidal and matrix-supported cultures for mimicking the three-dimensional environment of organs like the liver.
The organ models are connected by microfluidic channels. An on-chip pump enables a near lifelike nutrient and oxygen supply to the cells. This allows for detailed studies of distribution and metabolization of various substances like drugs, cosmetics, chemicals, and food additives enabling the prediction of substance effects.The HUMIMIC Chip2 is designed for use with non-invasive in-process controls like fluorescence microscopy and other optical methods.
A control unit like the HUMIMIC Starter is necessary to operate the HUMIMIC Chip2.
Features
- Efficient lifelike tissue nutrition
- Flexible combination of different tissues
- Compatible with different types of cell culture (primary cells, iPS-based models, biopsies)
- Long-term performance
- Physiological shear stress applicable
- Rapid prototyping for specific customer needs
HUMIMIC Chip3 and HUMIMIC Chip3plus
The HUMIMIC Chip3 is designed for the simultaneous cultivation of up to three organ models in a common microfluidic circuit. The HUMIMIC Chip3 and HUMIMIC Chip3plus have all the advantages as the HUMIMIC Chip2 while allowing the culture of an additional organ model.
The HUMIMIC Chip3 and Chip3plus gives you additional flexibility when selection your cell cultures due to its tailored design approach featuring organ compartments of varying size. A control unit like the HUMIMIC Starter is necessary to operate the HUMIMIC Chip3.
Features
- Efficient, lifelike nutrition of up to three organ models
- Flexible combination of different tissues
- Compatible with different types of cell cultures (primary cells, iPS-based models, biopsies)
- Long-term performance
- Physiological shear stress applicable
- Rapid prototyping for specific customer needs
HUMIMIC Chip4
The HUMIMIC Chip 4 enables easy integration of up to four different organ models, e. g. a combination of intestine, liver, kidney and neuronal tissue in one system.
The PBPK-compliant design allows for quantitative in vitro to in vivo extrapolation. The HUMIMIC Chip 4 uses two separate microfluidic circuits to model processes like excretion and reabsorption of various substances in the kidney model.
Features
Efficient, lifelike tissue nutrition of up to four organ models
Supports relevant PK/PD modeling for quantitative in vitro to in vivo extrapolation and determination of ADME profiles (absorption, distribution, metabolism and excretion)
- Long-term repeated performance
- Physiological shear stress applicable
- Enables multi-organ disease modelling
HUMIMIC Starter:
Our specialist for individual missions
Compact yet powerful, the HUMIMIC Starter is a stand-alone unit or in a combination of multiple devices, it can do everything from basic research to complex studies.
HUMIMIC AutoLab:
Our answer to the big questions
The HUMIMIC AutoLab can independently run up to 24 chips simultaneously. It can do everything the HUMIMIC Starter can do, and a lot more in an automated and more convenient way.
HUMIMIC AutoPlant:
Nobody can change the world on their own
The HUMIMIC AutoPlant is on your side when it comes to detailed and complex experiments and studies. It can be expanded with an infinite number of modules, giving you all the research capacity you will ever need.
